The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs

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The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs.

The pharmacokinetics of diminazene aceturate following intramuscular (i.m.) administration at 4.2 mg/kg was evaluated in 8 healthy German Shepherd dogs. Blood samples were collected at 19 intervals over a period of 21 days. Diminazene plasma concentrations were measured using a validated HPLC method with UV detection and a sensitivity of 25 ng/ml. The in vitro and in vivo binding of diminazene ...

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The intravenous pharmacokinetics of diminazene in healthy dogs.

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The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.

Diminazene aceturate is a commonly used antibabesial agent. It has been postulated that diminazine may induce a decrease in blood pressure and exacerbate the hypotension presented in dogs with babesiosis. This study was undertaken to assess the effect of diminazine aceturate on the blood pressure of healthy dogs. Six healthy German shepherd dogs between 18 and 24 months of age with a mean weigh...

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ژورنال

عنوان ژورنال: Journal of the South African Veterinary Association

سال: 2005

ISSN: 2224-9435,1019-9128

DOI: 10.4102/jsava.v76i3.416